Country/Region: Brazil
PE Guidelines

Methodological Guidelines: Economic Evaluation of Health Technologies (2014)
PDF in Portuguese

PE Guidelines Source:

Brazil Ministry of Health
http://www.saude.gov.br

Additional Information:
Last Webpage Update: Monday, January 15, 2018

PE Guidelines Key Features:

Key Features:  
Title and year of the document
Methodological Guidelines: Economic Evaluation of Health Technologies (2014)  
Affiliation of authors
Universities, government. 
Purpose of the document
Contribute to the standardization of the local studies in order to improve transparency, review and reproduction of them. 
Standard reporting format included
Yes 
Disclosure
Yes 
Target audience of funding/ author's interests
Either those who conduct HE evaluation or those who evaluate such studies (decision makers) 
Perspective
Preferably the one of the public payer. Societal perspective also possible  
Indication
Approved indications 
Target population
Clearly specified 
Subgroup analysis
When either there is a group of similar alternatives or a variability in clinical practice among a subgroup of patients 
Choice of comparator
Most prevalent treatment in the public system, most used treatment   
Time horizon
It must have as a basis the natural history of the disease in order to capture all relevant costs and consequences 
Assumptions required
Yes 
Preferred analytical technique
Cost-consequence Analysis, CMA, CEA, CUA, CBA   
Costs to be included
It depends on the perspective of the study: direct costs with/without indirect costs. 
Source of costs
Government databases and other public databases when necessary   
Modeling
Yes 
Systematic review of evidences
Yes 
Preference for effectiveness over efficacy
Yes. Efficacy has to be converted into effectiveness by means of appropriate methods. Details must be provided. 
Preferred outcome measure
Effectiveness 
Preferred method to derive utility
standard gamble, time trade-off, personal trade-off or visual analogue scale.  
Equity issues stated
Yes   
Discounting costs
Base case: 5% (0%-10% in S.A.) 
Discounting outcomes
Base case: 5% (0%-10% in S.A.) 
Sensitivity analysis-parameters and range
For all uncertain parameters, a plausible range must be defined for each parameter. A 2nd order Monte Carlo simulation to be used when applicable. 
Sensitivity analysis-methods
One-way, multi-way, probabilistic analysis 
Presenting results
The report has to be clear, detailed and transparent. A 3-page executive summary must be written in a context accessible to a non-technical reader.   
Incremental analysis
Yes 
Total costs vs effectiveness (cost/effectiveness ratio)
Yes 
Portability of results (Generalizability)
Yes; details must be provided. 
Financial impact analysis
Yes 
Mandatory or recommended or voluntary
Recommended 

Acknowledgement: Mario Giorgio Saggia highly contributed to the key features form. Mario Giorgio Saggia, Managing Director, Asigma, São Paulo, Brazil

Country Selection Page | PE Guidelines Index Page